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Do you have a particular issue when trying to open it now - slow load time, crashes, other?
Look through the presentation and blog post below for some tips:
SF19US - 08 Taking a bite out of 100GB files (Betty DuBois)
PCAP Split and Merge
Too bad I can't find the profiles Betty is referring to. Does anyone where to find them?
Packet Detectives - Resources
Got it. Thanks.